We share a key publication for the LAL-D community
From the association, we want to highlight an essential scientific review: “Best Practices for the Nutritional Management of Infantile-Onset Lysosomal Acid Lipase Deficiency: A Case-Based Discussion”, published in the journal Nutrients.
This publication brings together available evidence and real-world clinical experience from physicians and metabolic dietitians to provide practical guidance on the nutritional care of infants with infantile-onset LAL-D, a rare and rapidly progressive disease known as Wolman Disease.
What does this review offer?
- Explains the pathophysiology of LAL-D and how it affects lipid metabolism and digestive function.
- Addresses the main nutritional challenges, such as fat and protein malabsorption, micronutrient deficiencies, and growth failure.
- Provides step-by-step recommendations for nutritional interventions: low-fat formulas, supplementation, and specialized feeding strategies.
- Includes real clinical cases showing how tailored nutrition combined with enzyme replacement therapy (sebelipase alfa) improves long-term outcomes.
Additionally, the publication includes tables, figures, and modular recipes to facilitate implementation in clinical practice.
Key points for the LAL-D community
- Nutritional management is critical alongside enzyme replacement therapy.
- Early diagnosis and strict adherence to a minimal-fat diet are essential to improve outcomes.
- Strategies must be individualized and adapted to clinical progression.
📌 You can read the full publication here: https://www.mdpi.com/2072-6643/18/2/233
A message for our community
Every scientific advance is a step toward a better life for those living with LAL-D. This publication reminds us that with knowledge, teamwork, and commitment, we can transform the reality of patients and their families.
You are not alone: together we continue building hope, support, and solutions.
